1,2-Dimethylhydrazine-Induced Colon Carcinoma and Lymphoma in msh2-/- Mice
نویسندگان
چکیده
منابع مشابه
Genetics of colon carcinogenesis in mice treated with 1,2-dimethylhydrazine.
Genetic analysis of colon tumor induction by symmetrical 1,2-dimethylhydrazine (DMH) was undertaken in F1, F2, and reciprocal backcross hybrids derived from a cross between two inbred mouse strains, the 100% susceptible ICR/Ha and completely resistant C57BL/Ha. Mice, 12 to 14 weeks old, received 22 successive weekly s.c. injections of 0.35% aqueous solution of DMH buffered to pH 6.5. A dose of ...
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Organosulfur compounds (OSCs) present in garlic and onion oil have been shown to inhibit chemical carcinogenesis. In this study, we compared the chemopreventive efficacy of five lipid- and four water-soluble OSCs using the murine nuclear aberration assay. Administration of diallyl sulfide and S-allyl cysteine p.o. at a dose of 200 mg/kg 3 h prior to i.p. 1,2-dimethylhydrazine (DMH) injection (2...
متن کاملDNA Alkylation in Mice with Genetically Different Susceptibility to 1,2-Dimethylhydrazine-induced Colon Carcinogenesis1
The formation and persistence of methylatedpurines was determinedin mice that receiveda singles.c. Injec tion of 1,2-[14Cjdimethylhydrazine (15 mg/kg) and were allowed to survive for 12 or 60 hr. In mice with a low susceptibilityto dlmethylhydrazine-lnducedcolon card nogenesis(C57BL/Ha), concentrationsof 7-methylguan inc and 06-methylguanlnein DNA of colon, ileum, and kidney were 40 to 60% less...
متن کاملChemoprevention of 1,2-Dimethylhydrazine-induced Colon Cancer in Mice by Naturally Occurring Organosulfur Compounds1
Organosulfur compounds (OSCs) present in garlic and onion oil have been shown to inhibit chemical carcinogenesis. In this study, we compared the chemopreventive efficacy of five lipidand four water-soluble OSCs using the murine nuclear aberration assay. Administration of diallyl sulfide and 5-allyl cysteine p.o. at a dose of 200 mg/kg 3 h prior to i.p. 1,2-dimethylhydrazine (DMII) injection (20...
متن کاملDNA alkylation in mice with genetically different susceptibility to 1,2-dimethylhydrazine-induced colon carcinogenesis.
The formation and persistence of methylated purines was determined in mice that received a single s.c. injection of 1,2-[14C]dimethylhydrazine (15 mg/kg) and were allowed to survive for 12 or 60 hr. In mice with a low susceptibility to dimethylhydrazine-induced colon carcinogenesis (C57BL/Ha), concentrations of 7-methylguanine and O6-methylguanine in DNA of colon, ileum, and kidney were 40 to 6...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 2001
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/93.20.1534